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Pinch the skin to lift a fold of fat, insert the needle at a 45- or 90-degree angle (depending on needle length and tissue thickness), and inject slowly

Following OA induction, the rabbits were randomly divided into four groups with 8 subjects, each receiving a different weekly intra-articular treatment starting four weeks after the first collagenase injection

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Walker 2020 AOD-9604 Dosage Protocol: Subcutaneous Injection Timing For subcutaneous research use, 250500 mcg once daily is the standard starting range