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Their approach: aspirate the hemarthrosis within 1-2 weeks of injury removing the inflammatory environment from the joint then deliver anakinra (IL-1 receptor antagonist) directly into the knee during that narrow biological window

Secondary site: Near the lateral epicondyle (bony prominence on the outer knee) and the fibular head (the small bump below and to the outside of the knee)

Olincy A, Blakeley-Smith A, Johnson L, Kem WR, Freedman R (2016) Brief report: initial trial of alpha7-nicotinic receptor stimulation in two adult patients with autism spectrum disorder

This concept has contributed to interest in combination therapy research involving cagrilintide

The mechanisms here are less well characterized than in musculoskeletal tissue, but the consistent finding of preserved dopaminergic tone in BPC-157-treated animals has generated interest in potential applications for neurodegenerative conditions