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Weight loss was also assessed in the SCALE Sleep Apnea RCT, in which 359 non-diabetic individuals (mean age 48.5 years, mean BMI 39.1 kg/m 2 ), mostly males with untreated obstructive sleep apnea (OSA), were enrolled to investigate the effect of liraglutide on disease severity 20

Large-scale metabolic profiling can be conducted (Figure 3) using a variety of biological samples, including specific cells, biological fluids, and tissues, generating detailed metabolic reports

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The consequence is easy to understate: a substantial fraction of the evidence that DSIP exists endogenously and varies with sleep rests on assays that cannot fully distinguish DSIP from related material

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