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Recently, in 2016, a phase 2 trial (N = 332 LOE1a) showed that daily administration of 1500 mg LC or mecobalamin resulted in significant reductions in neuropathy symptom score and neuropathy disability score in diabetic patients

This is because it contains eight hydrophilic OH groups, so its ratio of carbon atoms to hydrophilic groups is 128 = 1.51, which is less than 31

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