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A randomized phase II clinical trial of personalized peptide vaccination with metronomic low-dose cyclophosphamide in patients with metastatic castration-resistant prostate cancer

Data-Driven Adjustments: Resist the urge to make arbitrary changes

Upregulation of oxidative mitochondrial metabolism is an accepted method of resistance to other therapeutic interventions in various diseases, such as pancreatic cancer and acute myeloid leukaemia 67,68

Childs AJC, Kaminski T, Halliwell B, Leuwenburgh C: Supplementation with vitamin C and N-acetyl-cysteine increases oxidative stress in humans after an acute muscle injury induced by eccentric exercise

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