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Lancet 2:579581 James LP, Farrar HC, Sullivan JE, Givens TG, Kearns GL, Wasserman GS, Walson PD, Hinson JA, Pumford NR (2001) Measurement of acetaminophen-protein adducts in children and adolescents with acetaminophen overdoses

doi: 10.1080/19336918.2019.1629224 31 CardonaA

JAKs can link to multiple STATs, with STATs being the final effectors of signaling, and the combinations can be activated to regulate transcription, mediating processes like apoptosis, proliferation, differentiation, and cell migration [117, 118]

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This orthogonal mechanism makes the combination a research model for studying receptor cross-talk in neuroendocrine signaling