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Materials and methods Study approval and registration The investigator-initiated GSH-MAP study (ClinicalTrials.gov Identifier: NCT 03596125) was conducted in the Department of Obstetrics (2018-2021), funded by the University-Hospital of Nantes, and approved by the medical ethical committee ( CPP-EST I , N2017/65), besides the National Agency for the Safety of Medicines and Health Products (N EudraCT 2017-003999-31)

For NAC intervention experiments, rats were co-treated with N-acetylcysteine (NAC, Sigma Aldrich

As a positive control, we used a -Secretase inhibitor IV (BACE) to see if we can reduce the AD pathology

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L-(cysteine), L-(glutamic acid), (glycine)