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A systematic review of data from patients with heart failure, atrial fibrillation, myocardial infarction, hypertension, atherosclerosis, ischemic heart disease, or undergoing cardiothoracic surgery identified a variety of beneficial cardiovascular effects of NAC [174]

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10.1093/jac/dkm121 16 GoswamiM.MangoliS

may marginally improve stability Avoid: Tap water, distilled water without sterilization, or solutions containing oxidizing agents Reconstitution Protocol Allow lyophilized vial to reach room temperature before opening Clean vial septum with alcohol swab Add diluent slowly along vial wall (not directly onto powder) Allow powder to dissolve without shaking

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