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2.4.3 Association between microplastics and neurodegenerative disorders Microplastics can promote neuronal apoptosis and dysfunction by inducing oxidative stress and neuroinflammation (25),the bioaccumulation of microplastics leads to protein aggregation within neurons, further exacerbating the neurodegenerative process.After oral administration, polystyrene nanoplastics (PS-NPs) can cross the blood-brain barrier (BBB) and distribute in regions such as the cortex, hippocampus, substantia nigra pars compacta (SNc), and striatum of mouse brains