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To address this knowledge gap, we have developed a series of genetic models that permit spatiotemporal control over the expression of GCLC, the rate-limiting enzyme in GSH synthesis

In parallel, they exert significant immunomodulatory effects: polysaccharides stimulate the immune system's antitumor response by activating macrophages, T lymphocytes, natural killer cells, and dendritic cells, and by promoting the release of cytokines such as TNF-, IFN-, and IL-2 (134)

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This functional complexity also makes the ankle vulnerable to injuries that can become chronic problems when healing does not proceed optimally