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UPLC-TOF MS metabolite analysis and bioinformatic gene cluster analysis highlighted dipeptides rather than single amino or hydroxy acids as the basic modules in tetradepsipeptide assembly and proposed the CesA C-terminal C* domain and the CesB C-terminal TE domain to function as a cooperative esterification and depsipeptide elongation center repeatedly recruiting the action of the C* domain to oligomerize tetradepsipeptides prior to the release of cereulide from the TE domain by macrocyclization

SS-31 directly targets the mitochondrial dysfunction that is a primary mechanism of taxane and platinum-based chemotherapy neurotoxicity

Entering total days instead of exact hours when using the custom time gap feature

Engineering quaternized chitosan in the 3D bacterial cellulose structure for antibacterial wound dressings

24%) at six-month follow-up