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Therapeutic peptides generally have very favorable safety profiles, they are short amino acid chains that the body recognizes as biological molecules rather than foreign compounds, and they are cleared naturally

Their detoxification systems are rarely robust, and much of this has been traced to an insufficient amount of glutathione activity

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In the N-acetyl form, an acetyl group is added to the N-terminus of the four-residue chain, a modification commonly used in peptide chemistry to alter charge, lipophilicity, and resistance to aminopeptidase activity relative to the unmodified peptide