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(A, B) Top 10 upregulated gene pathways according to KEGG database (A) and WikiPathways (BD) Top 10 downregulated gene pathways according to KEGG database (C) and WikiPathways (D)

1 -Adrenergic receptors mediate coordinated Ca 2+ signaling of cortical astrocytes in awake, behaving mice

17 A key characteristics of pain related to IC/BPS is that the pain is worsened with bladder filling (painful bladder filling) and/or their strong urge to urinate was due to pain, pressure, or discomfort (painful urgency)