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Many PCOS-focused trials use a 40:1 ratio of MI to DCI, which mirrors the physiological balance observed in healthy ovarian tissue.1 39 At a practical level, inositol dosing can be grouped by how its been studied: General metabolic and insulin support PCOS and reproductive health In PCOS research, the most common protocol is 2,000mg of MI taken twice daily (4,000mg total) , sometimes paired with 50100mg of DCI in a 40:1 ratio

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In addition, both riboflavin and PLP are essential determinants of the kynurenine pathway which influence glutamate receptors, hence, glutamate excitotoxicity potential, as shown in Section Riboflavin as a Determinant of the Kynurenine Pathway. Concerning PD, glutamate excitotoxicity contributes to dopaminergic neuronal loss (84)

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