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Although the drug was administered topically, systemic suppression of VEGF occurred, suggesting potential off-target effects beyond the ocular compartment (Sultana and Scondotto 2020)

Niacinamide strengthens the skin barrier, improves elasticity, and supports ceramide synthesis, helping the skin become smoother and more resilient

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Comparative analysis found GHK-Cu improved collagen production in 70% of treated women, compared to 50% with vitamin C cream and 40% with retinoic acid

Combinations with physical therapy for musculoskeletal injuries, with standard medical therapy for gastrointestinal conditions, or with other regenerative peptides such as growth hormone secretagogues could provide synergistic benefits