As a key structural component of the endothelial barrier, glycocalyx integrity is vital for maintaining microvascular homeostasis across multiple organs [22, 60]
It can be stabilized in a bilayer by utilizing bilayer lipids such as phosphatidylserine (PS) or a weakly acidic amphiphile, cholesteryl hemisuccinate (CHEMS) [83]
Symptoms of deficiency include decreased appetite, weight loss, chronic diarrhea, lethargy and weakness, anemia, and neurological abnormalities
Chemically, it is a tripeptide compound consisting of 3 amino acids which are glutamic acid, cysteine and glycine [4]
The biggest gaps: tesamorelin is the only one with FDA approval and Phase III data showing visceral fat reduction