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When polyunsaturated fatty acids stimulate cells to produce RSL-3 to induce ferroptosis, monounsaturated fatty acids like oleic acid may neutralize and protect cells from ferroptosis ( in vivo and in vitro models, only one type of phosphatidylethanolamine phospholipid has been identified as a lipid that induces ferroptosis

In some of such embodiments, the formulation is useful in perfusion of otic structures, e.g., during surgery

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Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice

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