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Meanwhile, M2 macrophages-derived extracellular vesicle (EVs) could also convert activated M1 macrophages into M2 macrophages through in situ macrophage reprogramming and producing a distinct protein expression pattern characteristic of anti-inflammatory M2 macrophages

A lack of Sirt1 activity is associated with several aspects of senescence, including SASP activation [240] and cell cycle arrest [241], as well as senescence-associated degenerative pathologies including neurodegeneration, cachexia, fatty liver, and atherosclerosis [5,86]

10.1016/j.cell.2019.07.008 96 RomO.LiuY.LiuZ.ZhaoY.WuJ.GhrayebA.et al (2020)

However, no causal effect between the intake of other antioxidant diets and vitiligo was found

Assists the anti-aging process**