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Tefferi A, Li CY, Butterfield JH, Hoagland HC
Disclosure of interest: Rebecca Menkhaus: nothing to disclose, Johannes Teller: nothing to disclose, Annika Grosshennig: nothing to disclose, Rieke Ringlstetter: nothing to disclose, Ilai Kaulbarsch: nothing to disclose, Lara Clow: nothing to disclose, Ralf Lichtinghagen: nothing to disclose, Hannelore Ehrenreich: nothing to disclose, Karin Weissenborn: nothing to disclose, Gerrit M
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Inhibit osteoclast activation and differentiation, reduce bone resorption Block osteoclast differentiation signal RANKL/RANK/OPG pathway: AOD 9604 downregulates the expression of RANKL (a key factor in osteoclast differentiation) and upregulates the expression of OPG (a RANKL antagonist), reducing the RANKL/OPG ratio by 50-60% and blocking the differentiation of osteoclast precursors into mature osteoclasts
Patients seek treatment for medically-confirmed B12 deficiency causing fatigue, neurological symptoms, or anemia
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