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P values indicated, calculated by one-way ANOVA with Dunnetts multiple comparisons test ( a,c ), two-tailed t -test ( b ) or two-way ANOVA with dks multiple comparisons test

This is an inherited genetic disease called pyroglutamic aciduria which manifests as hemolytic anemia and metabolic acidosis, causing neurological disorders and vulnerability to bacterial infections, and which can be classified as mild, moderate or severe depending on the severity of the symptoms

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We consider it a precursor to glutathione