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Additionally, another SOD mimic, GC4419, 580 has demonstrated good safety in phase II clinical trials among head and neck cancer patients suffering from severe oral mucositis induced by radiation and chemotherapy (NCT02508389)

Some randomized controlled trials combining topical + oral glutathione observed statistically significant improvements in skin brightness and melanin index around 8 weeks

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Cold Spring Harb Perspect Biol 13(4):a040584 Chattopadhyay R, Dyukova E, Singh NK, Ohba M, Mobley JA, Rao GN (2014) Vascular endothelial tight junctions and barrier function are disrupted by 15 (s)-hydroxyeicosatetraenoic acid partly via protein kinase c-mediated Zona occludens-1 phosphorylation at threonine 770/772

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