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Normative melatonin excretion: a multinational study

For example, precipitation events affect particular regions over relatively short time periods (hours to weeks), but the human extraction of water from the environment for cities or for use in agriculture can alter entire ecosystems for years, decades, or longer

Nutrition & Food Research 59 (7), 13641372

Those following vegetarian or vegan diets, individuals with absorption issues such as Crohns or celiac disease, people taking certain medications, or older adults may be at greater risk of deficiency

Used as forever therapy, they are something else, and we will get into that on a separate post