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NPJ Schizophr

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Clinical Evidence: REDEFINE Program# REDEFINE 1 (Without Type 2 Diabetes)# 3,417 adults randomized to CagriSema (n=2,108), semaglutide alone (n=302), cagrilintide alone (n=302), or placebo (n=705) for 68 weeks

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2024;10:e33905

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It has an essential role in energy production, DNA repair, and cellular regeneration

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Aging disrupts this niche support, driving a transition toward a pro-inflammatory transcriptional state

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