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An earlier study of HIV suggested that auranofin induces apoptosis in HIV-infected memory T lymphocytes, which are the most important reservoir of latent HIV, under increased cellular oxidative stress due to the inhibition of TRXR [84]
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SCFAs could have a binding regulatory effect on inflammatory diseases by controlling the migration of immune cells towards the site of inflammation and modulating their activity, allowing the rapid elimination of pathogens by activating ROS
Acknowledgements We appreciate the statistical help of Paul Shragg and Reena Deutsch, PhD, of the NIH/NCRR-sponsored UCSD Clinical Research Center (MO1-RR00827)
The activities of the enzymes involved in GSH metabolism are controlled at transcriptional, translational, and post-translational levels
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