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Preclinical studies document significant brain concentrations after systemic (including oral) administration, with behavioral improvements in hippocampal-dependent tasks confirming functionally relevant CNS penetration (PMID: 23055539)

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Last updated: April 2026 UK research-grade reference For laboratory research use only not for human consumption Quick answer: Published rodent pharmacokinetic data suggest BPC-157 has a relatively short serum half-life (estimated minutes to a few hours), yet produces sustained pharmacodynamic effects over days to weeks

Rashki et al., 2021)