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Wu H, Tuli L, Bennett GN, San KY

While current treatments largely focus on symptom relief, agents such as Wnt pathway modulators (e.g., lorecivivint), ADAMTS-5 inhibitors, and nerve growth factor (NGF) antagonists like tanezumab are under investigation for their potential to alter disease progression (Jiang et al., 2021

20 It is worth noting that gene polymorphisms of liver metabolic enzymes, such as UGT , SULT , and CYP2E1 , and some co-existing diseases, such as viral hepatitis, acute and chronic malnutrition, and nonalcoholic fatty liver disease, may increase the susceptibility to APAP-induced liver injury, even at a therapeutic dose

[Google Scholar] Amar MJ, DSouza W, Turner S, Demosky S, Sviridov D et al

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