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1-4 It is a cellular reductant, catalyst, and reactant involved in many biologic processes of transport, metabolism, storage, and protection

Yet, it is certain that a deficient BBB would contribute to disease pathogenesis in a self-perpetuating cycle, and blood-borne immune cells or toxins could further accelerate neuroinflammation and Lewy body pathology

Homeostasis refers to an ideal regulated value or level

419,420 Although UPR modulation holds substantial promise, successful translation will require a nuanced understanding of context-specific UPR signaling across disease stages