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[138] [139] In 1964 the United States Surgeon General's Report on Smoking and Health demonstrated the relationship between smoking and cancer

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First, a longer duration of use means a longer cumulative exposure to nicotine and free radicals

For example, as vaping among young people continues to grow, we need to know more about how exposure early in life to nicotine and other vaping components affects the heart and the lungs, which are still developing in adolescence