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Rayyan software (Ouzzani et al., 2016) was employed for reference management, including the identification and removal of duplicate entries

In adipose tissue, inhibition of NNMT suppresses de novo lipogenesis, normalizes fat content, and improves insulin sensitivity 2-3

PubMed Gwyer, D., Wragg, N.M., Wilson, S.L

Questions remaining include optimal human dosing, long-term safety, effects across different populations, interactions with diet and exercise, and whether benefits extend beyond weight loss to improvements in cardiometabolic disease outcomes