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ROXY9 is oxidized to ROXY9-S 2 depending on the redox potential of the GSH/GSSG couple, while class I GRXs adopt a stable equilibrium between the glutathionylated and the S 2 -containing state over a wide range of redox potentials established by GSH/GSSG

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From 1,309 bioactive molecules screened, the computer analysis selected GHK at 1 micromolar and securinine at 18 micromolar as the optimal agents capable of reversing expression of 54 gene sets overexpressed in malignant invasive colon cancer

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