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The half-life may be prolonged two-fold or more in patients with liver dysfunction

This behavior of the GS flux is caused by the competition between the higher inhibition of GS and GCL by GSH and the higher stimulation of GCL by estradiol [Figure 2]

800,801 These early studies showed that a metallochaperone forms a ligand-exchange labile coordination complex with a specific metal and exploits the specificity of proteinprotein interactions to transfer the metal to an acceptor or client protein (Figure 34, top )

Tang et al., 2022

Gold chloride metallic salts with a 49% purity from Sigma-Aldrich was utilized for this study