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In children, it is most commonly associated with sulfa drugs and anticonvulsants.1 Typically, the clinical picture develops between 4 and 28 days (most frequently 1015 days) after starting treatment.2 Involvement of the oral, ocular, gastrointestinal, and genital mucosa is very common.1 The incidence of EN and the associated mortality appear to be lower in children than adults

Animal studies document faster muscle fiber regeneration and improved tensile strength in BPC-157-treated subjects compared to control groups

Thus, glutamine entry into the TCA cycle can provide metabolic intermediates for NRF2-regulated NADPH-producing enzymes, such as IDH1 and ME1

Perhaps in future clinical trials, the lung dead-space fraction will be included in the grouping criteria

This advisory committee meeting is a formal step in the process of resolving that uncertainty one way or the other