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In addition, transgenic mice that express human catalase targeted to the mitochondria exhibited less severity of age-related OA compared to WT mice [143]

Moreover, mtDNA and nuclear DNA in the mitochondrion cause it to receive the regulation of two sets of genetic information, and may also get the mutation of two kinds of genome, making the treatment more complicated

Is this a typical presentation for an iron overdose

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Am J Physiol Renal Physiol 2002