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Research demonstrates that TB-500 administration mobilizes EPCs from bone marrow reservoirs, with animal studies showing 3-fold increases in circulating EPC numbers that contribute to neovascularization through both structural incorporation into developing vessels and paracrine secretion of pro-angiogenic factors

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We did not observe changes in type I collagen, probably due to its high enrichment in EFT-412 skin tissue that is reconstructed from adult cells