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Bone and Joint Manifestations of Inflammatory Bowel Disease Spondyloarthropathy Axial skeleton Sacroiliitis Ankylosing spondylitis Peripheral Type 1 (oligoarticular) Type 2 (polyarticular) (rare) Abbreviations: CD, Crohn disease

The range reflects the uncertainty in sublingual bioavailability

Phase 2 trial (NEJM 2023) used a structured ramp to 12 mg/week but at trial doses of 8 mg and 12 mg, dropout from gastrointestinal events was substantial

Pretreatment continued for 20 min before PE was added

112 For example, the AMP named Cecropin-XJ isolated from Xinjiang silkworm was found to have the ability to combine with the groove of tumor cell DNA and then insert into the DNA sequence, resulting in the disordered arrangement of base pairs and looseness of DNA double helix structure, leading to DNA damage and cell death