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We and others also demonstrated that hemin induces the expression of NRF2 in SCD erythroblasts and animal models and such effect is mitigated by administration of dimethyl fumarate (DMF) 23,24 , an FDA-approved drug for the treatment of multiple sclerosis

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Consistent with this hypothesis, EVs collected after the last bout of training possessed unique cargo, including metabolite interconversion enzymes, and induced beneficial changes in mouse models that are reflective of EV turnover