PMID: 138 RidlonJIkegawaSAlvesJZhouBKobayashiAIidaTet al
The PI3K/Akt pathway in meta-inflammation
Rosmarinic acid (25 and 50 mg/kg, p.o., 4 weeks) effectively relieved oxidative stress (e.g., lipid peroxidation, nitrite levels, and DNA fragmentation), improved mitochondrial function, prevented the loss of ATP levels, reduced spinal cord inflammation (e.g., TNF- and IL-6), and, meanwhile, maintained the levels of phosphorylated adenosine 5-monophosphate-activated protein kinase (AMPK) in the sciatic nerves, thus, significantly reversing the mechanical allodynia and cold hyperalgesia in rats of PIPN ( Overall, antioxidant drugs, traditional medicines, extracts, as well as active ingredients have been proven to open new horizons for overcoming PIPN
The tech who started last month
R., Sobey, C