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A healthy human body, on the other hand, can synthesize enough -lipoic acid to scavenge reactive oxygen species and increase endogenous antioxidants

doi: 10.1089/ars.2007.1865

However, during inflammatory reactions, exposure of macrophages to interferon (IFN) and TNF results in the activation of the inducible isoenzyme of NOS (iNOS), which increases up to 10 times the levels of nitric oxide