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The Randall plaque doctrine suggests that kidney stones begin as calcium plaques on the basement membrane of the loop of Henle, and that large numbers of idiopathic CaOx stones attach to the plaques to form deposits deep in the renal interstitium

doi:10.1007/bf02284971

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Allergens or toxins in the urine are thought to cause the bladder walls to become sensitized to increased mast cells.[ref][ref][ref] Vulvodynia and mast cell activation: Vulvodynia is a chronic genital pain condition that includes an increased number of mast cells