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Its anti-inflammatory effects work through nitric oxide regulation, which is distinct from NSAID mechanisms and carries fewer GI risks

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A consensus on the management of chronic ataxias in adulthood has also outlined recommendations [181], proposing varenicline, a partial agonist of the 42 nicotinic acetylcholine receptor, for the treatment of ataxia in SCA3 (grade B recommendation) [180, 182]

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