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"Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging." Cell

Specifically, the cells basal OCR, maximal OCR, and spare respiratory capacity were not impacted after 24 hours of incubation with 1 M CB-839 ( Supplemental Figure 6 )

Nature 475:471476

Copper is a required cofactor for lysyl oxidase (connective-tissue crosslinking), for superoxide dismutase (antioxidant defense), and for enzymes that support angiogenesis, so a molecule that delivers copper in a controlled, cell-usable form has a coherent reason to influence tissue remodeling and vascular biology

Weight loss helps normalize the metabolic processes in the liver, reducing the amount of uric acid produced