220 found that the methylation levels of four ER genes including ERO1LB , NFE2L2 , MBTPS1 and EIF2AK4 which encoded ER oxidoreductin-1 (ERO1), nuclear factor-erythroid 2-related factor (Nrf2), site-1 protease (S1P) and eIF-2-alpha kinase (GCN2) respectively, were strongly correlated with total body fat levels
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doi: 10.1042/bj2270833 Kuchel, PW, Chapman, BE, Endre, ZH, King, GF, Thorburn, DR and York, MJ (1984)
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Specifically, a dose of 200 mg/kg SAE demonstrated the most significant benefits, characterized by a marked reduction in reactive oxygen species (ROS) production, an enhancement of antioxidant defenses within the lens, a decrease in lipid peroxidation, a suppression of apoptotic processes, and an increase in cell proliferation