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However, these agents often lack selectivity, potentially causing unnecessary damage and apoptosis in normal cells (Marcus et al., 2018

108 In March 2015, the FDA required a black box warning on Tanzeum due to the observed risk of thyroid C-cell tumors in animals, although it is unclear if this effect also occurs in humans

However, oxidative stress or GSH depletion causes TXNIP to dissociate from TXN and instead bind to NLRP3, inducing conformational activation and promoting inflammasome assembly 53,54

Exosomes in intercellular communication and implications for osteoarthritis

After reconstitution with bacteriostatic water, refrigerate at 2-8C and use within 14-21 days