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10.1016/j.yexcr.2024.114053 142 YuanS.ChuY.LiuF.XiaoY

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Ostrowska JK, Wojtukiewicz MZ, Chabielska E, Buczko W, Ostrowska H

The peptide demonstrates dual-phase mechanisms: acute phase preservation of ischemic tissue through anti-apoptotic signaling via Akt activation, and chronic phase activation of cardiac progenitor cells (c-kit+ populations) that contribute to myocardial repair through both structural replacement and paracrine support, with studies showing 200% increases in progenitor cell mobilization and cardiac homing