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In order to establish the role of AC metabolism in depression risk, we previously [32] leveraged summary-level data from large GWAS (up to ~800,000 samples) and Mendelian randomization analyses to examine the potential reciprocal relationships between circulating levels of 15 ACs and depression

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SAAR diverts glucose toward asparagine synthesis Given that loss of hepatic PSAT1 blunted, but did not completely abolish the improvement in glucose tolerance by SAAR, we further examined how SAAR could be influencing glucose metabolism in the liver

Thus, owing to their ability to accumulate preferentially in macrophages, IONPs offer promising prospects for novel therapeutic strategies, intending to harness the immune systems strength to combat diseases such as cancer or infections