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In this study, we found CHII blocked glycosuria-caused calorie loss and compensatory polyphagia (Figures 2A, C, 3A, C) via promoting urine concentration (Figures 2A, 3A) by up-regulation of renal water reabsorption associated proteins (Figures 2H, I, 3G, H), thereby, as a consequence, hyperglycemia was alleviated pronouncedly (Figures 2D, 3D) in alloxan-induced diabetic mice

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It often comes down to a handful of critical variables that can turn a smooth study into a complicated one

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