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Overall these data indicates that the lack of sufficient DHA or its deficient supply is accompanied by increased Gpx4 mRNAs expression and GPx4 protein synthesis, which consequently augment cellular resistance to oxidative damage of DHA-containing phospholipids

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However, in a recent study on the inhibition of Hepa1-6 cell proliferation induced by oxidative stress, we found that increased expression of GPX6 protein may play a role in inhibiting oxidative stress ( 2.7 GPX7 Glutathione peroxidase 7 (GPX7) is a non-selenocysteine active neutral antioxidant enzyme in mammals, also known as non-selenium cysteine phGPX (NPGPX) due to its homology to phospholipid peroxide GPX (phGPX = GPX4) ( E