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Cell culturing of primary fibroblasts Fibroblasts, established from skin biopsies of the patients (Table S2) or purchased by a commercial vendor (NHDF, #CC-2509, Lonza) were cultured in high glucose Dulbeccos Modified Eagle Medium (Life Technologies, Carlsbad, CA, USA, 41966029) supplemented with 10% fetal bovine serum (Life Technologies, 10270106), 50 U/mL penicillin/streptomycin (Life Technologies, 15070063), and 200 M uridine (Sigma, St

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Seeking medical attention at the first signs of toxicity significantly improves outcomes and reduces the risk of liver failure

This is a second-generation product