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Further research will likely discover other compounds to have glial cell modulating properties, and opioid antagonists similar to naltrexone, such as nalmefene [51], may be good targets for further study

Many identified metabolites, such as those containing sulfur and phenol, are known to be toxic to enterocytes, disrupt intercellular tight junctions (TJ), and stimulate bacterial translocation, all of which support this idea (van der Poll et al., 2017)

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High-dose niacin therapy is normally contraindicated in individuals with active peptic ulcer disease or active liver disease