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This is a normal and temporary reaction, indicating the treatment has successfully targeted the pigment

In addition, it has long been known that GSH is capable of forming disulfide bonds with cysteine residues of proteins, and the relevance of this mechanism (S-glutathionylation) in regulation of protein function has been well documented in a number of research fields

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10.1016/j.freeradbiomed.2022.02.028 Free Radic Biol Med

In some embodiments, the otic formulation or composition comprises about 18% by weight of the viscosity modulating agent(s)